Biological Information

Background Information:

N-terminal 6His-tagged, recombinant, human WNK1, amino acids 1-491. WNK1 is an atypical serine/threonine kinase involved in regulating ion transport and blood pressure by modulating sodium and potassium channels. Gain-of-function mutations increasing WNK1 expression have been found in patients with familial hypertension and several studies have suggested that WNK1 also plays an important role in cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL), where it may serve as a druggable target.

Target Class:

Kinase

Family:

WNK

Sub Family:

Serine/threonine kinase

Protein Name:

WNK1

Accession Number:

NM_018979.1

UniProt Number:

Q9H4A3

Gene Name:

WNK1

Gene ID:

65125

Gene Aliases:

KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

Radiometric

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Hypertension/Oncology