SCF beta-TrCP1 complex, active

Background Information:

The SCF beta-TrCP1 complex is a multi-subunit E3 ubiquitin ligase belonging to the SCF (Skp1–Cullin–F-box) family. It consists of Skp1, Cul1, Rbx1 and the F-box substrate-recognition subunit beta-TrCP1. The complex serves as a critical regulator of multiple signaling pathways, including NF-kappaB, Wnt/beta-catenin, and DNA damage response networks. Through these roles, it influences cell proliferation, differentiation, immune activation, and oncogenesis. Beta-TrCP1 can act either as a tumor promoter (e.g. through degradation of I?B-alpha and activation of NF-kappa-B signaling) or as a tumor suppressor (e.g., by targeting beta-catenin or CDC25A). This context dependence makes it a nuanced target in cancer therapeutics.

Target Class:

Ubiquitination-related

Family:

F-box protein

Sub Family:

E3 Ligase

Protein Name:

beta-TrCP1

Protein Aliases:

beta-TRCP; E3RSIkappaB; BTRCP, FBW1A, FBXW1A (beta-TrCP1)

Accession Number:

NM_033637.2 (beta-TrCP1); NM_170679.2 (Skp1); NM_003592.2 (Cul1); NM_014248.2 (Rbx1)

UniProt Number:

Q9Y297 (beta-TrCP1)

Gene Name:

BTRC (beta-TrCP1)

Gene ID:

8945 (beta-TrCP1)

Gene Aliases:

FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP (beta-TrCP1)

Target Species:

Human