Biological Information

Background Information:

PrecisION™ hNav1.5 (HEK 293) Ready-to-Assay Frozen Cells provide an easy-to-use cell based assay to study Nav1.5 ion channels, including drug candidates which affect channel function. These Ready-To-Assay Frozen Cells enable assessment of ion channel function via detection of electrophysiological signals. The included cells overexpress Nav1.5 ion channels. Upon voltage-induced channel activation, response can be detected via automated or manual electrophysiological techniques. These cells are provided as single-use vials of cryopreserved cells.

Target Class:

Ion Channel

Family:

Sodium

Sub Family:

Voltage-Gated

Protein Name:

Nav1.5

Protein Aliases:

long QT syndrome 3

Accession Number:

NM_000335

UniProt Number:

Q14524

Gene Name:

SCN5A

Gene ID:

6331

Gene Aliases:

Nav1.5|LQT3|HB1|HBBD|PFHB1|IVF|HB2|HH1|SSS1|CDCD2|CMPD2|ICCD

Target Species:

Human

Cell Background:

HEK293

Usage

Product Type:

Frozen Cells

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Electrophysiology

Detection Method:

Electrophysiology

Additional Information

Brand:

PrecisION™