PKR, active

Background Information:

Protein kinase RNA-regulated (PKR), an ubiquitous serine/threonine kinase that is induced by interferons, is a critical signal transducer implicated in different stress-induced signaling pathways including dsRNA-induced TLR3 signaling and LPS-induced TLR4 signaling. Upon stress stimulation, PKR is activated by autophosphorylation and subsequently phosphorylates the alpha-subunit of eukaryotic initiation factor 2 (eIF-2a) thereby inducing apoptosis. PKR mediates the activation of important transcription factors, such as NF-kB, and MAP kinases, such as p382, by interacting with the TAK1 complex. GenBank NM_002759.1

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

PKR

Protein Aliases:

protein phosphatase 1, regulatory subunit 83

Accession Number:

NM_002759.1

UniProt Number:

P19525

Gene Name:

EIF2AK2

Gene ID:

5610

Gene Aliases:

PKR|EIF2AK1|PPP1R83|PRKR

Target Species:

Human