PDK1, active

Background Information:

Phosphoinositide-Dependent Kinase-1 (PDK1) plays a central role in mediating cell signaling between PI3K and various intracellular serine/threonine kinases by phosphorylating many other kinases including PKC, p70S6 kinase, ribosomal S6 kinase, p21-activated kinase, PKC-related kinase, PKB and serum glucocorticoid kinase. PDK1 interacts with a wide range of substrates, and has been found to regulate apoptosis, cell proliferation and survival through the PI3K signaling pathway. A PDK1 inhibitor may be of therapeutic use in the treatment of human cancers and diabetes. GenBank AF017995

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

PDK1

Protein Aliases:

PkB kinase

Accession Number:

NM_002613.3; NM_031268.4

UniProt Number:

O15530

Gene Name:

PDPK1

Gene ID:

5170

Gene Aliases:

PDK1

Target Species:

Human