PathHunter® U2OS TrkC Bioassay Kit

Background Information:

The PathHunter® TrkC Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay kit enables assessment of ligand (e.g. NT-3) based activation of TrkC receptors via detection of SH2 domain protein recruitment. The included cells overexpresses ProLink-tagged TrkC target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

TRKC

Protein Aliases:

GP145-TrkC|Trk-C|Neurotrophic tyrosine kinase receptor type 3|TrkC tyrosine kinase

Accession Number:

NM_001012338

UniProt Number:

Q16288

Gene Name:

NTRK3

Gene ID:

4916

Gene Aliases:

TRKC

Target Species:

Human

Cell Background:

U2OS