PathHunter® HEK 293 RELA Nuclear Translocation Cell Line

Background Information:

The PathHunter® HEK 293 RELA Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the NFκB pathway. This cell line enables assessment of ligand (e.g. wortmannin) based pathway activation via detection of resulting RELA nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged RELA and nuclear localized EA. Upon pathway activation, induced nuclear translocation of RELA leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Family:

Transcription factor

Protein Name:

RELA

Protein Aliases:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|Transcription factor p65

Accession Number:

NM_021975

UniProt Number:

Q04206

Gene Name:

RELA

Gene ID:

5970

Gene Aliases:

NFKB3

Target Species:

Human

Cell Background:

HEK293