Biological Information
Background Information:
The PathHunter® IL22RA/IL10RB1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-22) induced dimerization of IL22RA/IL10RB1 receptors. This product uses EFC technology. The cell line included overexpresses IL22RA target protein fused to PK alongside IL10RB1 target protein fused to EA. Upon ligand-induced dimerization of IL22RA/IL10RB1 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
Cytokine Receptor
Family:
IL-10 Receptor
Protein Name:
IL22RA1
Protein Aliases:
IL-22R-alpha-1|IL-22RA1|Cytokine receptor class-II member 9|Cytokine receptor family 2 member 9|CRF2-9|ZcytoR11
Accession Number:
NM_021258.3
UniProt Number:
Q8N6P7
Gene Name:
IL22RA1
Gene ID:
58985
Gene Aliases:
IL22R
Target Species:
Human
Cell Background:
HEK293
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®