PathHunter® GPR1 Total GPCR Internalization U2OS Cell Line

Background Information:

The PathHunter® GPR1 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. chemerin) based internalization of GPR1 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses PK-tagged GPR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the GPR1 receptor to the early endosome leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemerin

Sub Family:

Class A

Protein Name:

GPR1

Protein Aliases:

G protein-coupled receptor 1

Accession Number:

NM_005279

UniProt Number:

P46091

Gene Name:

GPR1

Gene ID:

2825

Target Species:

Human

Cell Background:

U2OS