Biological Information
Background Information:
The PathHunter® mMC4R Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. α-MSH) based activation of mMC4R GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mMC4R and EA-tagged β-Arrestin-2. Activation of mMC4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:
GPCR
Family:
Melanocortin
Sub Family:
Class A
Protein Name:
MC4
Accession Number:
NM_016977.1
UniProt Number:
P56450
Gene Name:
Mc4r
Gene ID:
17202
Target Species:
Mouse
Cell Background:
CHO-K1
Usage
Product Type:
Cell Pool
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®