Biological Information

Background Information:

The PathHunter® mMC4R Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. α-MSH) based activation of mMC4R GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mMC4R and EA-tagged β-Arrestin-2. Activation of mMC4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

GPCR

Family:

Melanocortin

Sub Family:

Class A

Protein Name:

MC4

Accession Number:

NM_016977.1

UniProt Number:

P56450

Gene Name:

Mc4r

Gene ID:

17202

Target Species:

Mouse

Cell Background:

CHO-K1

Usage

Product Type:

Cell Pool

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

β-Arrestin Recruitment

Detection Method:

Chemiluminescence

Additional Information

Brand:

PathHunter®