PathHunter® C2C12 KISS1R β-Arrestin Cell Line

Background Information:

The PathHunter® KISS1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. [ligand]) based activation of KISS1R GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged KISS1R and EA-tagged β-Arrestin 2. Activation of KISS1R stimulates the recruitment of β-Arrestin 2 and produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Kisspeptin

Sub Family:

Class A

Coupling:

Gq

Protein Name:

KiSS1 (GPR54)

Protein Aliases:

G-protein coupled receptor 54|G-protein coupled receptor OT7T175|hOT7T175|Hypogonadotropin-1|Kisspeptins receptor|Metastin receptor

Accession Number:

NM_032551

UniProt Number:

Q969F8

Gene Name:

KISS1R

Gene ID:

84634

Gene Aliases:

HOT7T175|AXOR12|GPR54

Target Species:

Human

Cell Background:

C2C12