p70 S6 Kinase, active

Background Information:

p70 S6 Kinase, also known as RPS6KB1 (Ribosomal Protein S6 Kinase B1) is a Protein Coding gene. This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. GenBank M60724. The recombinant protein contains an amino acid substitution, T412E, with reference to M60724. This mutation mimics phosphorylation of T412 and facilitates activation by PDK1.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

p70S6K

Protein Aliases:

S6K1|70 kDa ribosomal protein S6 kinase 1|P70S6K1|p70-S6K 1|Ribosomal protein S6 kinase I|Serine/threonine-protein kinase 14A|p70 ribosomal S6 kinase alpha|p70 S6 kinase alpha|p70 S6K-alpha|p70 S6KA

Accession Number:

NM_003161.2; T412E

UniProt Number:

P23443

Gene Name:

RPS6KB1

Gene ID:

6198

Gene Aliases:

S6K1|p70(S6K)-alpha|PS6K|STK14A

Target Species:

Human