Biological Information

Background Information:

JTV1 (p38) is a structural subunit of the multi-aminoacyl-tRNA synthetase complex. It plays additional regulatory roles beyond translation, for example stabilizing p53 by inhibiting MDM2-mediated ubiquitination and degradation of p53, thereby acting as a pro-apoptotic factor. It also mediates ubiquitination and degradation of FUBP1, a transcriptional activator of Myc, leading to Myc down-regulation which is required for aveolar type II cell differentiation.

Target Class:

Ubiquitination-related

Family:

AIMP

Sub Family:

Multifunctional scaffolding protein

Protein Name:

JTV-1

Protein Aliases:

p38; JTV-1; JTV1; AIMP2

Accession Number:

BC002853.1

UniProt Number:

Q13155

Gene Name:

AIMP2

Gene ID:

7965

Gene Aliases:

P38; JTV1; HLD17; JTV-1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

ECL

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology