MLK3, active

Background Information:

MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

MLK3

Protein Aliases:

Mixed lineage kinase 3|Src-homology 3 domain-containing proline-rich kinase

Accession Number:

NM_002419.2

UniProt Number:

Q16584

Gene Name:

MAP3K11

Gene ID:

4296

Gene Aliases:

MLK3|PTK1|SPRK

Target Species:

Human