Biological Information

Background Information:

MYLK (myosin light polypeptide kinase; myosin light chain kinase, MLCK), which belongs to the family of Ca2+/calmodulin (CaM)-dependent protein kinases, induces a high degree of myosin motor activity by specifically phosphorylating the myosin II regulatory light chain (MRLC). Myosin II phosphorylation is involved in smooth muscle contraction and cell motility in non-muscle cells. GenBank NM_053025

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

MLCK

Protein Aliases:

smooth muscle myosin light chain kinase

Accession Number:

NM_014791.2

UniProt Number:

Q15746

Gene Name:

MYLK

Gene ID:

4638

Gene Aliases:

MLCK|smMLCK|MYLK1|MLCK1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology