MKK4/SKK1, unactive

Background Information:

MKK4 is a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. EMBL U18310

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

MKK4

Protein Aliases:

MAPKK 4|JNK-activating kinase 1|MAPK/ERK kinase 4|MEK 4|SAPK/ERK kinase 1|SEK1|Stress-activated protein kinase kinase 1|SAPK kinase 1|SAPKK-1|SAPKK1|c-Jun N-terminal kinase kinase 1|JNKK

Accession Number:

U18310.1

UniProt Number:

P47809

Gene Name:

Map2k4

Gene ID:

26398

Gene Aliases:

MEK4|JNKK1|PRKMK4|MKK4|MAPKK4|SAPKK1|SKK1|JNKK|SEK1

Target Species:

Mouse