MAP Kinase 3/Erk1, unactive

Background Information:

MAP Kinase 1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. Involved in both the initiation and regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). Gen Bank XM_055766

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

ERK1

Protein Aliases:

MAPK 3|ERT2|Extracellular signal-regulated kinase 1|ERK-1|Insulin-stimulated MAP2 kinase|MAP kinase isoform p44|p44-MAPK|Microtubule-associated protein 2 kinase|p44-ERK1

Accession Number:

NM_002745.4; NM_138957.2

UniProt Number:

P27361

Gene Name:

MAPK3

Gene ID:

5595

Gene Aliases:

ERK1|p44mapk|p44erk1|PRKM3

Target Species:

Human