Lyn, active

Background Information:

The Lyn protein is a member of the Src family of non-receptor-associated protein-tyrosine kinases. LYN A differs from LYN B in having an additional 21 amino acids at the amino terminus. Lyn undergoes a concentration-dependent autophosphorylation, thus activating the catalytic site and decreasing the accessibility of the SH2 domain. Lyn phosphorylates and activates Tec, non-receptor tyrosine kinase that is coexpressed with Lyn and acts downstream of Lyn in intracellular signaling pathways. Lyn tyrosine kinase has been shown to be necessary for IgE-receptor (FceRI)-mediated mast-cell activation. EMBL M16038

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

LYN

Protein Aliases:

Lck/Yes-related novel protein tyrosine kinase|V-yes-1 Yamaguchi sarcoma viral related oncogene homolog|p53Lyn|p56Lyn

Accession Number:

NM_002350.1

UniProt Number:

P07948

Gene Name:

LYN

Gene ID:

4067

Gene Aliases:

JTK8

Target Species:

Human