GCK, active

Background Information:

GCK (Glucokinase) is a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. GenBank BC047865

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

GCK

Protein Aliases:

B lymphocyte serine/threonine-protein kinase|Germinal center kinase|GC kinase|MAPK/ERK kinase kinase kinase 2|MEK kinase kinase 2|MEKKK 2|Rab8-interacting protein

Accession Number:

NM_004579.2

UniProt Number:

Q12851

Gene Name:

MAP4K2

Gene ID:

5871

Gene Aliases:

GCK|BL44|RAB8IP

Target Species:

Human