Biological Information

Background Information:

Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. EphB3 (Ephrin type-B receptor 3, ETK2, HEK2, TYRO6) has been found that nearly all receptors and ligands are expressed in developing and adult neural tissue. GenBank NM_004443

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphB3

Protein Aliases:

EPH-like tyrosine kinase 2|EPH-like kinase 2|Embryonic kinase 2|EK2|hEK2|Tyrosine-protein kinase TYRO6

Accession Number:

NM_004443.3

UniProt Number:

P54753

Gene Name:

EPHB3

Gene ID:

2049

Gene Aliases:

Hek2|Tyro6

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology