ChemiSCREEN™ GPR54/KiSS1 Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ GPR54/KiSS1 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of KISS1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses KISS1R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of KISS1R , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Kisspeptin

Sub Family:

Class A

Protein Name:

KiSS1 (GPR54)

Protein Aliases:

G-protein coupled receptor 54|G-protein coupled receptor OT7T175|hOT7T175|Hypogonadotropin-1|Kisspeptins receptor|Metastin receptor

Accession Number:

NM_032551

UniProt Number:

Q969F8

Gene Name:

KISS1R

Gene ID:

84634

Gene Aliases:

HOT7T175|AXOR12|GPR54

Target Species:

Human

Cell Background:

Chem-1