ChemiSCREEN™ ETA Endothelin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ ETA Endothelin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. endothelin) based activation of EDNRA GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses EDNRA alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of EDNRA , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Endothelin

Sub Family:

Class A

Protein Name:

ETA

Protein Aliases:

ET-A|ET-AR

Accession Number:

S63938

UniProt Number:

P25101

Gene Name:

EDNRA

Gene ID:

1909

Target Species:

Human

Cell Background:

Chem-1