ChemiSCREEN™ CCR4 Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CCR4 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TARC, MDC) based activation of CCR4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR4 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR4 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CCR4

Protein Aliases:

CC-CKR-4|CCR-4|CCR4|K5-5|CD antigen CD194

Accession Number:

X85740

UniProt Number:

P51679

Gene Name:

CCR4

Gene ID:

1233

Gene Aliases:

CC-CKR-4|CMKBR4|CKR4|k5-5|ChemR13|CD194

Target Species:

Human

Cell Background:

Chem-5