cAMP Hunter™ DLD1 PTGER2 Gs Cell Line

Background Information:

The cAMP Hunter™ PTGER2 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of PTGER2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGER2 , a naturally Gs coupled GPCR. Upon activation of PTGER2 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Prostanoid

Sub Family:

Class A

Coupling:

Gs

Protein Name:

EP2

Protein Aliases:

PGE2 receptor EP2 subtype|Prostanoid EP2 receptor

Accession Number:

AY275471

UniProt Number:

P43116

Gene Name:

PTGER2

Gene ID:

5732

Gene Aliases:

EP2

Target Species:

Human

Cell Background:

DLD1