cAMP Hunter™ CHO-K1 CXCR3 Gi Cell Line

Background Information:

The cAMP Hunter™ CXCR3 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL11/I-TAC) based activation of CXCR3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CXCR3 , a naturally Gi/Go coupled GPCR. Upon activation of CXCR3 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

CXCR3

Protein Aliases:

CXCR-3|CKR-L2|G protein-coupled receptor 9|Interferon-inducible protein 10 receptor|IP-10 receptor|CD antigen CD183

Accession Number:

AY242128

UniProt Number:

P49682

Gene Name:

CXCR3

Gene ID:

2833

Gene Aliases:

CKR-L2|CMKAR3|IP10-R|MigR|CD183

Target Species:

Human

Cell Background:

CHO-K1