Biological Information
Background Information:
The cAMP Hunter™ TACR3 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. senktide, neurokinins) based activation of TACR3 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type TACR3 , a naturally Gs coupled GPCR. Upon activation of TACR3 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Tachykinin
Sub Family:
Class A
Coupling:
Gq & Gs
Protein Name:
NK3
Protein Aliases:
neurokinin beta receptor
Accession Number:
NM_001059
UniProt Number:
P29371
Gene Name:
TACR3
Gene ID:
6870
Gene Aliases:
NK3R|TAC3R
Target Species:
Human
Cell Background:
CHO-K1
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
cAMP Detection
Detection Method:
Chemiluminescence
Additional Information
Brand:
cAMP Hunter™