cAMP Hunter™ CHO-K1 SSTR3 Gi Cell Line

Background Information:

The cAMP Hunter™ SSTR3 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin 28) based activation of SSTR3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type SSTR3 , a naturally Gi/Go coupled GPCR. Upon activation of SSTR3 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Somatostatin

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

sst3

Protein Aliases:

SS3-R|SS3R|SSR-28

Accession Number:

AY322541

UniProt Number:

P32745

Gene Name:

SSTR3

Gene ID:

6753

Target Species:

Human

Cell Background:

CHO-K1