cAMP Hunter™ CHO-K1 CCR1 Gi Cell Line

Background Information:

The cAMP Hunter™ CCR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL3) based activation of CCR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CCR1 , a naturally Gi/Go coupled GPCR. Upon activation of CCR1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

CCR1

Protein Aliases:

CC-CKR-1|CCR-1|CCR1|HM145|LD78 receptor|Macrophage inflammatory protein 1-alpha receptor|MIP-1alpha-R|RANTES-R|CD antigen CD191

Accession Number:

NM_001295

UniProt Number:

P32246

Gene Name:

CCR1

Gene ID:

1230

Gene Aliases:

CKR-1|MIP1aR|CD191

Target Species:

Human

Cell Background:

CHO-K1