c-Kit, active

Background Information:

Binding of stem cell factor (SCF) to C-Kit receptor tyrosine kinase induces homodimerization and intermolecular tyrosine phosphorylation of the receptor, creating docking sites for a number of SH2-containing signal transduction molecules. These include phosphatidylinositol 3'-kinase (PI 3K) and phospholipase C-1, Stat1, the Src family kinases Src, Lyn, and Fyn, and the GTPase activating protein GAP. Mutation in Kit which result in ligand-independent activation of the kinase were found to be associated with human gastrointestinal stromal tumors and mastocytosis. GenBank X06182

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Kit

Protein Aliases:

Piebald trait protein|PBT|Proto-oncogene c-Kit|Tyrosine-protein kinase Kit|p145 c-kit|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog|CD antigen CD117

Accession Number:

NM_000222.2; NM_001093772.1

UniProt Number:

P10721

Gene Name:

KIT

Gene ID:

3815

Gene Aliases:

CD117|SCFR|C-Kit

Target Species:

Human