ALK1, active

Background Information:

ALK1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. GenBank L17075.1

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK1

Protein Aliases:

Activin receptor-like kinase 1|ALK-1|TGF-B superfamily receptor type I|TSR-I

Accession Number:

L17075.1

UniProt Number:

P37023

Gene Name:

ACVRL1

Gene ID:

94

Gene Aliases:

HHT2|ALK1|HHT|ACVRLK1

Target Species:

Human