U2OS GPR39 Gq Cell Line

Background Information:

The GPR39 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. Zn2+) based activation of GPR39 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GPR39 , a naturally Gq coupled GPCR. Upon activation of GPR39 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Class A Orphan

Sub Family:

Orphan and other 7TM

Coupling:

Gq

Protein Name:

GPR39

Accession Number:

NM_001508

UniProt Number:

O43194

Gene Name:

GPR39

Gene ID:

2863

Target Species:

Human

Cell Background:

U2OS