SHP-2

Background Information:

SHP-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. GenBank X70766

Target Class:

Phosphatase

Family:

Non-Receptor

Sub Family:

Protein Tyrosine

Protein Name:

SHP2

Accession Number:

X70766

UniProt Number:

Q06124

Gene Name:

PTPN11

Gene ID:

5781

Gene Aliases:

BPTP3|SH-PTP2|SHP-2|PTP2C|SHP2

Target Species:

Human