Ready-to-Assay GLP-2 Receptor Frozen Cells

Background Information:

The Ready-to-Assay GLP-2 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. GLP-2) based activation of GLP2R GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress GLP2R alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of GLP2R , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

Glucagon

Sub Family:

Class B

Protein Name:

GLP-2

Protein Aliases:

GLP-2-R|GLP-2R

Accession Number:

NM_004246

UniProt Number:

O95838

Gene Name:

GLP2R

Gene ID:

9340

Target Species:

Human

Cell Background:

Chem-11