PathHunter® U2OS mPD-L1 Ligand Cell Line

Background Information:

The PathHunter® mPD-L1 Ligand cell line is a stable, engineered cell line designed for use with mPD-1 Checkpoint Signaling Cell Lines. When co-cultured, the mPD-L1 expressed in this cell line will induce activity of mPD-1 receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses mPD-L1 cell surface ligand. When co-cultured with the corresponding Checkpoint Signaling Cell Line, the mPD-L1 ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note this product expresses the mouse version of PD-L1.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor Ligand

Protein Name:

PD-L1

Protein Aliases:

PDCD1 ligand 1|CD274 molecule|B7 homolog 1|B7-H1|CD antigen CD274

Accession Number:

NM_021893

UniProt Number:

Q9EP73

Gene Name:

Cd274

Gene ID:

60533

Gene Aliases:

B7h1|Pdl1|Pdcd1l1|Pdcd1lg1|A530045L16Rik

Target Species:

Mouse

Cell Background:

U2OS