Biological Information
Background Information:
The PathHunter® mBRS3 Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. bombesin) based activation of mBRS3 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mBRS3 and EA-tagged β-Arrestin-2. Activation of mBRS3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:
GPCR
Family:
Bombesin
Sub Family:
Class A
Protein Name:
BB3
Accession Number:
NM_009766.3
UniProt Number:
O54798
Gene Name:
Brs3
Gene ID:
12209
Gene Aliases:
BB3|BB3R|BBR3
Target Species:
Mouse
Cell Background:
U2OS
Usage
Product Type:
Cell Pool
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
β-Arrestin Recruitment
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®