PathHunter® LAIR1 Signaling Cell Line (Jurkat)

Background Information:

The PathHunter® LAIR1 Signaling Cell Line (Jurkat) is a stable, engineered cell line for use in studying drug candidates targeting signaling checkpoints. This cell line enables assessment of ligand based activation of LAIR1 receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged LAIR1-1 target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor

Protein Name:

LAIR1

Accession Number:

NP_002278.2

UniProt Number:

Q6GTX8

Gene Name:

LAIR1

Gene ID:

3903

Gene Aliases:

CD305|LAIR-1

Target Species:

Human

Cell Background:

Jurkat