LRRK2, active

Background Information:

This protein is a member of the leucine-rich repeat kinase family and encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

LRRK2

Protein Aliases:

Dardarin

Accession Number:

BC117180

UniProt Number:

Q5S007

Gene Name:

LRRK2

Gene ID:

120892

Gene Aliases:

ROCO2|DKFZp434H2111|FLJ45829|RIPK7

Target Species:

Human