InCELL Hunter™ A549 PYK2 Kinase Binding Cell Line

Background Information:

The InCELL Hunter™ A549 PYK2 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of PYK2 via detection of PYK2 levels. This product uses EFC technology. The cell line included overexpresses PYK2 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

PYK2

Protein Aliases:

Calcium-dependent tyrosine kinase|CADTK|Calcium-regulated non-receptor proline-rich tyrosine kinase|Cell adhesion kinase beta|CAK-beta|CAKB|Focal adhesion kinase 2|FADK 2|Proline-rich tyrosine kinase 2|Related adhesion focal tyrosine kinase|RAFTK

Accession Number:

NC_001147.6

UniProt Number:

Q14289

Gene Name:

PTK2B

Gene ID:

2185

Gene Aliases:

CAKB|PYK2|RAFTK|PTK|CADTK|FAK2

Target Species:

Human

Cell Background:

A549