ChemiSCREEN™ CCR3 Chemokine Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CCR3 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. eotaxin) based activation of CCR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR3 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CCR3

Protein Aliases:

CC-CKR-3|CCR-3|CCR3|CKR3|Eosinophil eotaxin receptor|CD antigen CD193

Accession Number:

U28694

UniProt Number:

P51677

Gene Name:

CCR3

Gene ID:

1232

Gene Aliases:

CC-CKR-3|CKR3|CD193

Target Species:

Human

Cell Background:

Chem-1