CHO-K1 GALR2 Gq Cell Line

Background Information:

The GALR2 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. galanin) based activation of GALR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GALR2 , a naturally Gq coupled GPCR. Upon activation of GALR2 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Galanin

Sub Family:

Class A

Coupling:

Gq & Gs

Protein Name:

GAL2

Protein Aliases:

GALR-2

Accession Number:

NM_003857

UniProt Number:

O43603

Gene Name:

GALR2

Gene ID:

8811

Gene Aliases:

GALNR2

Target Species:

Human

Cell Background:

CHO-K1