Biological Information

Background Information:

Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer. GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect to GenBank NM_003600. This substitution is reported in GenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

Aurora-A

Protein Aliases:

protein phosphatase 1, regulatory subunit 47|Aurora-A kinase

Accession Number:

NM_003600

UniProt Number:

O14965

Gene Name:

AURKA

Gene ID:

6790

Gene Aliases:

BTAK|AurA|STK7|ARK1|PPP1R47|AIK

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology